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Molecular Devices en chiffres : les instruments les plus cités de l’industrie*


45 200

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4 060

SoftMax Pro
9 630

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56 900


Repoussez les limites de la recherche fondamentale, de la recherche traductionnelle, de la découverte de médicaments et du développement de produits biologiques avec des produits utilisés par des milliers de scientifiques dans le monde et cités dans leurs publications.

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Dernières citations

Recherche fondamentale




Intestinal epithelial cell injury is rescued by hydrogen sulfide

B Li, A Zani, Z Martin, C Lee, E Zani-Ruttenstock… - Journal of pediatric …, 2016 - Elsevier
... treatment, 0.5 mg/ml MTT (ATCC, Manassas, VA) was added to the medium for 3 h incubation,
the insoluble formazan crystals within the cells were extracted by DMSO, and the absorbance
was measured using a microplate reader (Molecular Devices SpectraMax Gemini EM) at ...


Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology

E Candeias, AI Duarte, I Sebastião… - Molecular …, 2016 - Springer
... instructions. Briefly, 10 μL of each brain cortical homogenate were added to 1 mL
of Calimat reagent and the absorbance read at 550 nm, 37 °C, in a SpectraMax Plus
384 multiplate reader (Molecular Devices, Wokingham, UK). ...

A Reagent-Free Screening Assay for Evaluation of the Effects of Chemicals on the Proliferation and Morphology of HeLa-GFP Cells

S Cheng, J Li, G Su, RJ Letcher… - … Science & Technology …, 2016 - ACS Publications
... The proliferation and morphology of cells were monitored by use of a SpectraMax
i3Multi-Mode Microplate Reader (Molecular Devices, Sunnyvale, CA) every 24 h after
seeding. Data obtained were then used to produce growth curves. ...


S Khoury, A Ahadi, X Zhang, N Tran - Genomics data, 2016 - Elsevier
... Sex, Male and female. Sequencer or array type, LNA Exiqon array. Data format, Raw:
GenePix Results GPR File. Experimental factors, Tumour vs. normal. ... These were then
scanned with a Genepix 4000B Scanner (Axon Instruments, USA). ...


Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease

S Selvarajah, I Todd, PJ Tighe, M John… - Mediators of …, 2016 -
... cy5 (E-Biosciences, UK). The slides were scanned with a 4200 AL microarray scanner
at 635 nm (Axon GenePix®). Fluorescence was quantified using the GenePix Pro
Software (Axon GenePix). The median fluorescence of ...

Research data supporting" Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease"

FR Teixeira, SJ Randle, SP Patel, TET Mevissen… - 2016 -
... The arrays were washed with AB, once with distilled water, and finally dried by
centrifugation at 1000 × g for 2 min, before being scanned on a GenePix Personal
4100A (Axon–Molecular Devices). Data acquisition and analysis ...


Intracellular calcium measurements for functional characterization of neuronal phenotypes

T Glaser, ARG Castillo, Á OliveiraH Ulrich - Embryonic Stem Cell …, 2016 - Springer
... 2.3 Microfluorimetry. 2.3.1 Calcium Indicator Incorporation. Probenecid Stock Solution: Probenecid,
1 N NaOH, “Component B” buffer from FlexStation Calcium Assay Kit (Molecular Devices Corp.). ...
3.3 Calcium Microfluorimetry (FlexStation 3). 3.3.1 Calcium Indicator Incorporation ...

The Pharmacochaperone Activity of Quinine on Bitter Taste Receptors

JD UpadhyayaR Chakraborty, FA Shaik, A Jaggupilli… - PloS one, 2016 -
... extracellular. Changes in intracellular calcium were measured after addition of quinine
or yohimbine by FlexStation-3 microplate reader (Molecular devices), at 525 nm emission
following excitation at 494 nm. Brefeldin A treatment. T2R4 ...


Chemically induced hepatotoxicity in human stem cell-induced hepatocytes compared with primary hepatocytes and HepG2

SJ Kang, HM Lee, YI Park, H Yi, H Lee, BJ So… - Cell Biology and …, 2016 - Springer
... with 100 μl of fresh medium containing 10 % (v/v) 2-[4-Iodophenyl]-3-[4-nitrophenyl]-5-[2,4-
disulfophenyl]-2H-tetraxolium (WST) reagent (DoGEN, Republic of Korea) and again incubated
at 37 °C for 2 h. Absorbance was read using a luminometer (FlexStation III; Molecular ...


STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity.

S Varikuti, S Oghumu, G Natarajan… - International …, 2016 - Jpn Soc Immunol
... Cellular proliferation was analyzed using Softmax Pro software (Molecular Devices LLC) and
an online alamar blue reduction calculator (AbD Serotec, Raleigh, NC, USA). ... ELISA results were
analyzed using the Softmax Pro software (Molecular Devices LLC). Flow cytometry. ...

The interactions between piperonyl butoxide and analogues with the metabolic enzymes FE4 and CYP6CY3 of the green peach aphid Myzus persicae (Hemiptera: …

M Panini, F Tozzi, C Bass, CT Zimmer… - Pest management …, 2016 - Wiley Online Library
... readings every 20 s at 450 nm for 5 min. The integrated software programme Softmax
Pro version 5.4 was used ... 5 min at 405 nm. The integrated software programme Softmax
Pro version 5.4 was used to fit linear regressions. The ...



R Pamanji, B Yashwanth, JV Rao - Environmental Toxicology and …, 2016 - Elsevier
... The increase in absorbance was recorded immediately at 420 nm for 5 min (kinetic mode) in
a Spectrophotometer using SOFTmax Pro 5.4. ... The decrease in absorbance was recorded for
one minute at 240 nm using spectrophotometer supported by SOFTmax Pro 5.4. ...

Electrophysiological Tagging of Ionotropic Glutamate Receptors

A Barria - Ionotropic Glutamate Receptor Technologies, 2016 - Springer
... (a) Recording chamber. (b) Patch clamp amplifier (Axon Instruments, Multiclamp 700B). (c)
Micromanipulator for the recording electrode (Sutter, MPC 200). (d) Data acquisition software
(Axon Instruments, pClamp 10). (e) A/D board (Axon Instruments, Digidata 1322A). (f) ...



Microglia‐derived purines modulate mossy fibre synaptic transmission and plasticity through P2X4 and A1 receptors

J George, RA Cunha, C Mulle… - European Journal of …, 2016 - Wiley Online Library
... France) equipped with an infrared camera (VX44, Till Photonics, Gräfelfing, Germany) using an
Axoptach-200B amplifier (Axon Instruments, Sunnydale CA, USA). Signals were filtered at 2 kHz
and digitized at 5 kHz via a DigiData 1322A interface (Axon Instruments). ...

Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice

J Nomura, H Jaaro-Peled, E Lewis… - Molecular …, 2016 -
... Whole-cell current-clamp signals were amplified (10x) with a Multiclamp 700B (Axon
Instruments, Sunnyvale, CA, USA), digitized with an A/D converter (Digidata, Axon Instruments)
and sampled with Axoscope 9.0 (Axon Instruments) at 20 KHz. 41. ...


Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal Neurons

B Seifert, R Eckenstaler, R Rönicke, J Leschik, B Lutz… - Neural …, 2016 -
... 1-minute time-lapse recordings were analyzed with MetaMorph software (Molecular Devices,
Downington, PA, USA). ... Colocalization analysis was performed by MetaMorph software (Molecular
Devices, Downingtown, PA). 2.5. Preparation of Amyloid-Beta Oligomers. ...



Role of Acid Sphingomyelinase in Shifting the Balance Between Proinflammatory and Reparative Bone Marrow Cells in Diabetic Retinopathy

H Chakravarthy, S Navitskaya, S O'Reilly… - Stem …, 2016 - Wiley Online Library
... CACs were resuspended in electroporation solution (Lonza) to final concentration of 5 X 105
cells/100 µL, mixed with 300 nM ASM siRNA and electroporated (Nucleofector program M-030 ...
Length of primary dendrites of microglia was quantified using MetaMorph software...



Expression of a dynamin 2 mutant associated with Charcot-Marie-Tooth disease leads to aberrant actin dynamics and lamellipodia formation

H Yamada, K Kobayashi, Y Zhang, T Takeda… - Neuroscience …, 2016 - Elsevier
... FL). The confocal system was controlled by MetaMorph Software (Molecular Devices,
Sunnyvale, CA). Images ... Pro camera. Images were automatically captured every 10
s and processed by MetaMorph software. 2.6. Morphometry. ...


Découverte de médicaments


Comparative venomics reveals the complex prey capture strategy of the piscivorous cone snail Conus catus

SWA Himaya, AH JinS Dutertre… - Journal of proteome …, 2015 - ACS Publications
... High-throughput FLIPR assays revealed that the predation-evoked venom contained a range of conotoxins targeting the nAChR, Ca v , and Na v ion channels, consistent with α- and ω-conotoxins being used for predation by C. catus. ...


Discovery of inhibitors for the human chemokine receptors CXCR4 and CXCR7: screening applications on the FLIPR Tetra high-throughput cellular …

T D'huys, T Van Loy, D Schols - 2016 -
... ITEM METADATA RECORD. Title: Discovery of inhibitors for the human chemokine receptors
CXCR4 and CXCR7: screening applications on the FLIPR Tetra high-throughput cellular
screening system. Authors: D'huys, Thomas Van Loy, Tom Schols, Dominique. Issue Date:

Identification of State-Dependent Blockers for Voltage-Gated Calcium Channels Using a FLIPR-Based Assay

A di Silvio, JF Rolland, M Stucchi - High Throughput Screening: Methods …, 2016 - Springer
Abstract The FLIPR (Fluorescent Imaging Plate Reader) system has been extensively used 
in the early stages of drug discovery for the identification of small molecules as a starting 
point for drug development, and for the pharmacological characterization of compounds. 


The monitoring of gene functions on a cell-defined siRNA microarray in human bone marrow stromal and U2OS cells

HC Kim, GH Kim, D Shum, SG Cho, EJ Lee, YJ Kwon - Data in brief, 2016 - Elsevier
... in hBMSCs. (B) Quantitative analysis for p65 positive cells ratio and cell numbers
of (A). The figure images were acquired by an ImageXpress Ultra point scanning
confocal microscope with an anti-p65 antibody. Blue: Draq5 ...

High-throughput imaging: Focusing in on drug discovery in 3D

L Li, Q Zhou, TC Voss, KL Quick, DV LaBarbera - Methods, 2016 - Elsevier
... IN Cell Analyzer 6000, GE Healthcare, Confocal (laser based). ImageXpress Ultra, Molecular
Devices, Confocal (laser based). ImageXpress Micro Confocal, Molecular Devices, Confocal
(LED based). ... ImageXpress Velos, Molecular Devices, Laser-scanning fluorescence. ...

Oxysterols in adipose tissue-derived mesenchymal stem cell proliferation and death

SF Silva, D LevyJLM RuizTC de MeloC Isaac… - The Journal of steroid …, 2016 - Elsevier
... min. ImageXpress Micro high content screening system (Molecular Devices, CA,
USA) was used to determine the number of live and dead cells. ... min. The presence
of apoptosis was analyzed within 1 h using an ImageXpress...



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